期刊
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
卷 26, 期 11, 页码 1043-1061出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.trac.2007.09.004
关键词
active pharmaceutical ingredient; capillary electrophoresis; acid dissociation constant; liquid chromatography; potentiometry; spectrophotometry
The acid dissociation constant is an important physicochemical parameter of a substance, and knowledge of it is of fundamental importance in a wide range of applications and research areas. We present a critical review of published methods and approaches for the determination of acid dissociation constants, with a special emphasis on the pK(a) values of active pharmaceutical ingredients. (C) 2007 Elsevier Ltd. All rights reserved.
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