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New targets and emerging therapies for reducing LDL cholesterol

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CURRENT OPINION IN LIPIDOLOGY
卷 18, 期 6, 页码 650-655

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LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MOL.0b013e3282f169c6

关键词

apolipoprotein B; LDL-cholesterol; microsomal triglyceride transfer protein; proprotein convertase subtilisin kexin type 9; squalene synthase

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The emergence of modalities that act in series and in parallel with available agents may allow more effective LDL-cholesterol lowering in those patients intolerant of current therapy, and may permit clecremental reductions in LDL-cholesterol for those unable to achieve aggressive LDL-cholesterol goals using existing agents.

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