期刊
AMERICAN JOURNAL OF TRANSPLANTATION
卷 12, 期 9, 页码 2526-2531出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1600-6143.2012.04126.x
关键词
Antibody-mediated rejection; bortezomib; crossmatch; donor-specific antibodies; HLA compatibility; liver transplantation
资金
- NIDDK NIH HHS [T32 DK007191] Funding Source: Medline
Antibody-mediated rejection (AMR) is an uncommon, but challenging type of rejection after solid organ transplantation. We review three cases of AMR in ABO-compatible liver transplant recipients. These cases were characterized by severe acute rejection resistant to steroids and antithymocyte globulin, histologic evidence of plasma cell infiltrates, C4d positivity and high serum anti-HLA donor-specific antibodies. All three patients were treated with bortezomib, a proteasome inhibitor effective in depleting plasma cells. After treatment, all patients had improved or normal liver function tests, resolution of C4d deposition and significant decline in their HLA donor-specific antibodies.
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