期刊
AMERICAN JOURNAL OF TRANSPLANTATION
卷 12, 期 6, 页码 1486-1495出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1600-6143.2012.04080.x
关键词
Health-Related Quality of Life; health utilities; pediatric liver transplantation; outcomes
资金
- National Center for Research Resources, National Institutes of Health [KL2 RR025740 04]
- Foley Foundation
We conducted a cross-sectional study of patients who underwent pediatric liver transplant (LT) between 1988 and 1992 to evaluate long-term health status. Survivors completed socio-demographic, medical and Health-Related Quality of Life (HRQOL) surveys by mail including the SF-36v2, PedsQL (TM) 4.0 Generic Core Scale, PedsQL (TM) Cognitive Functioning Scale and PedsQL (TM) 3.0 Transplant Module. SF-36 scores were converted to SF6D-based utilities and risk factors for lower outcomes were assessed. Eighty-five of 171 patients had survived. Fifty-six were contacted with a response rate of 66%. Median age at LT was 0.86 years (IQR 0.583.0) and 64.3% had biliary atresia. Mean age at survey was 23.0 +/- 4.4 years: 62% attended college, 68% lived with parents and 80% of those over 23 were employed. Patient health utilities were lower than norms (0.75 +/- 0.12 vs. 0.82 +/- 0.18, p < 0.01) and correlated with unemployment (p < 0.042), hospitalizations (p < 0.005) and lower education level (p < 0.016). Lower PedsQL (TM) 3.0 Transplant Module and PedsQL (TM) 4.0 Generic Core Scale scores correlated with unemployment (p = 0.006, p = 0.009) and hospitalizations (p = 0.006, p = 0.02). Pediatric transplant recipients who survive to adulthood have lower physical HRQOL, measurable transplant-related disability and lower health utility. Transplantation is life saving; however, physical and psychological sequelae continue to affect health status up to two decades later.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据