期刊
AMERICAN JOURNAL OF TRANSPLANTATION
卷 12, 期 8, 页码 2072-2078出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1600-6143.2012.04055.x
关键词
Allograft; anti-CD45RB; regulatory B; TIM-1; tolerance
资金
- NIH [RO1AI057851-05, K01DK079207]
The role of B cells in transplant tolerance remains unclear. Although B-cell depletion often prolongs graft survival, sometimes it results in more rapid rejection, suggesting that B cells may have regulatory activity. We previously demonstrated that tolerance induction by anti-CD45RB antibody requires recipient B cells. Here, we show that anti-CD45RB in combination with anti-TIM-1 antibody has a synergistic effect, inducing tolerance in all recipients in a mouse islet allograft model. This effect depends on the presence of recipient B cells, requires B-cell IL-10 activity, and is antigen-specific. These data suggest the existence of a regulatory B-cell population that promotes tolerance via an IL-10-dependent pathway.
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