期刊
CORONARY ARTERY DISEASE
卷 18, 期 8, 页码 615-620出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MCA.0b013e3282f0efa5
关键词
carotid intima media thickness; coronary angiography; coronary; artery disease; isoprostanes; subclinical atherosclerosis
Objectives Cardiovascular diseases are the most common cause of death in the world. Oxidative stress has been proved to play a role in atherosclerotic diseases and 8-isoprostane is one of the most valid markers of in-vivo oxidative stress. We aimed to investigate the 8-isoprostane levels in relation to surrogate and direct angiographic indexes of atherosclerosis. Methods Urinary 8-isoprostane levels were measured and a B-mode carotid ultrasound examination was performed in 100 consecutive patients scheduled for coronary angiography. Results In patients with angiographic coronary artery disease (CAD) urinary 8-isoprostane levels were significantly (P < 0.001) higher than in patients without CAD (68.75 +/- 5.5 vs. 38.27 +/- 3.7 pg/ml). Moreover, 8-isoprostane levels of patients with increased carotid intima media thickness (CIMT) were higher (P < 0.001) than in patients with normal CIMT values (75.12 +/- 6.4 vs. 38.72 +/- 2.7 pg/ml). Moreover log(8-isoprostane) levels were significantly correlated with maximum and mean CIMT values (P < 0.001) and across univessel and multivessel CAD groups levels of log(8-isoprostane) showed a significantly (P < 0.001) increasing trend. Logistic regression analysis revealed that 8-isoprostane levels were an independent predictor for both intima-media thickening and angiographic CAD. Conclusion These findings indicate that elevated urinary levels of 8-isoprostane are associated with both subclinical atherosclerosis and manifest CAD. The results therefore support the hypothesis that isoprostanes-related oxidative stress is involved in the whole atherosclerotic process. Coron Artery Dis 18:615-620 (c) 2007 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
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