期刊
CURRENT OPINION IN CHEMICAL BIOLOGY
卷 11, 期 6, 页码 620-625出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2007.09.018
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资金
- NIGMS NIH HHS [R01 GM079465, R01 GM079465-01, T32 GM066698, R01 GM079465-03, GM079465, R01 GM079465-02] Funding Source: Medline
Nitric oxide (NO) and hydrogen peroxide (H2O2) have emerged as essential small molecules for cellular signal transduction owing largely to their ability to mediate oxidative posttranslational modifications (PTMs). Inventing new ways to track these small, diffusible, and reactive species with spatial and temporal resolution is a key challenge in elucidating their chemistry in living systems. Recent progress in the development of fluorescent probes that respond selectively to NO and H2O2 produced at cell signaling levels offers a promising approach to interrogating their physiological production, accumulation, trafficking, and function.
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