期刊
DNA REPAIR
卷 6, 期 12, 页码 1709-1725出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.dnarep.2007.05.009
关键词
family X polymerase; DNA polymerase beta; DNA polymerase lambda; TdT; DNA polymerase mu; gap-filling; misinsertion misalignment; frameshift lesion bypass; template-dependence; template-independence; substrate specificity
资金
- Intramural NIH HHS [Z99 ES999999] Funding Source: Medline
The mammalian family X DNA polymerases (DNA polymerases beta, lambda, mu, and TdT) contribute to base excision repair and double-strand break repair by virtue of their ability to fill short gaps in DNA. Structural information now exists for all four of these enzymes, making this the first mammalian polymerase family whose structural portrait is complete. Here we consider how distinctive structural features of these enzymes contribute to their biological functions in vivo. Published by Elsevier B.V.
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