期刊
GROWTH HORMONE & IGF RESEARCH
卷 17, 期 6, 页码 441-462出版社
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.ghir.2007.05.005
关键词
growth hormone; insulin-like growth factor I; GH deficiency; GH replacement; body composition; muscle strength; bone mineral density; neoplasia; cardiovascular disease; glucose metabolism
Growth hormone (GH) deficiency in adults is a recognised clinical entity. There is still, however, an ongoing debate of the clinical need and the importance of replacing GH in adults with severe GH deficiency. This review will focus on the overall management of adults with GH deficiency and highlight published data on dose management and treatment goals for various age groups. The efficacy data on quality of lit-e and well-being is discussed and available and growing experience oil long-term effects of GH replacement in adults and safety in terms of diabetes mellitus, pituitary tumour recurrence/regrowth and malignancy risk will be reviewed. (C) 2007 Elsevier Ltd. All rights reserved.
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