期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 192, 期 1-2, 页码 134-144出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2007.09.030
关键词
allogenicity; embryonic stem cells; Neu5Gc; oligodendrocyte progenitors
A major concern in the use of allotransplantation of human embryonic stem cell (hESC)-based therapies is the possibility of allogeneic rejection by the host's immune system. In this report, we determined the immunological properties of hESC-derived oligodendrocyte progenitor cells (OPC) that have the potential for clinical application for the treatment of patients with spinal cord injury. In vitro immunological studies suggest that hESC-derived OPCs are poor targets for both the innate and the adaptive human immune effector cells as well as resistant to lysis by anti-Neu5Gc antibodies. These results indicate that hESC-derived OPCs retain some of the unique immunological properties of the parental cell line from which they were differentiated. (c) 2007 Elsevier BN. All rights reserved.
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