期刊
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
卷 33, 期 3, 页码 191-198出版社
HUMANA PRESS INC
DOI: 10.1007/s12016-007-0045-4
关键词
atopic dermatitis; T cell; antigen-presenting cell; eosinophil; keratinocyte; superantigens; T regulatory cell
Atopic dermatitis (AD) is a highly pruritic, chronic, and relapsing inflammatory skin disease. Recent interest in AD has been sparked by reports of its increasing prevalence and its contribution to increasing health care costs. A precise understanding of immunologic mechanisms is crucial for the development of effective treatment strategies for AD. Various studies reveal that AD has a multifactorial cause with the activation of complex immunologic and inflammatory pathways. This review will discuss cellular-mediated immunological pathomechanisms of AD. Emphasis will be given to the role played by T cells, antigen-presenting cells, cosinophils, and keratinocytes. We also examine the immunological effect of superantigens on various inflammatory cells including T regulatory cells.
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