期刊
AMERICAN JOURNAL OF TRANSPLANTATION
卷 10, 期 5, 页码 1117-1125出版社
WILEY
DOI: 10.1111/j.1600-6143.2010.03087.x
关键词
Acute cellular rejection; memory T cells; T-cell immunity and transplantation; tolerance
资金
- NIAID NIH HHS [R01 AI040459] Funding Source: Medline
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI040459] Funding Source: NIH RePORTER
Studies in the past decade advanced our understanding of the development, execution and regulation of T-cell-mediated allograft rejection. This review outlines recent progress and focuses on three major areas of investigation that are likely to guide the development of graft-prolonging therapies in the future. The discussed topics include the contribution of recently discovered molecules to the activation and functions of alloreactive T cells, the emerging problem of alloreactive memory T cells and recently gained insights into the old question of transplantation tolerance.
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