期刊
MAGNETIC RESONANCE IN MEDICINE
卷 58, 期 6, 页码 1124-1134出版社
WILEY
DOI: 10.1002/mrm.21400
关键词
DCE-MRI; pharmacokinetic modeling; diffusion; perfusion; Gd-DTPA; vascularization
资金
- NIBIB NIH HHS [1 K25 EB005936-01] Funding Source: Medline
Standard two-compartment pharmacokinetic models that describe the dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) time course of gadolinium diethylenetriamine pentaacetic acid (Gd-DTPA) concentration in a tissue do not account for the passive diffusion of contrast agent (CA) from a well-perfused to a less vascularized region. Even when the arterial input function (AIF) is perfectly known, the standard Tofts model returns inaccurate values of K-trans (mean absolute relative difference [ARD] of 43%) from realistic simulated data where a well-defined delineation exists between a well-perfused and a poorly vascularized region. This contribution proposes a diffusion-perfusion (1313) model in which diffusion of a low molecular weight CA is incorporated in the standard two-compartment Tofts model. The proposed DID model reliably retrieved the values of K-trans and V-e (mean ARD of 16% and 17%, respectively) from simulated data. On mouse adenocarcinoma xenograft data showing evidence of CA diffusion, the standard model returned unphysical values of V-e in the tumor core whereas the proposed DIP model found values that were in the physical range (0 < V-e < 1) throughout the tissue. In addition, K-trans distributions from the DIP model more closely corresponded to the observed sharp delineation between highly and poorly perfused areas observed in the mouse tumors.
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