期刊
AMERICAN JOURNAL OF TRANSPLANTATION
卷 9, 期 12, 页码 2736-2744出版社
WILEY
DOI: 10.1111/j.1600-6143.2009.02847.x
关键词
Allograft; inflammation; T-reg; transplant; tolerance
资金
- [NIH R01 AI-048820]
- [K01 DK079207-02]
Innate immune signals foster adaptive immunity through activation of antigen-presenting cells. Recent in vitro evidence suggests that innate signaling may also contribute to immunity by countering the effects of regulatory T cells (T-regs), counter-regulation. We present in vivo evidence using a transgenic skin allograft model that the function of T-regs is lost in the setting of acute skin transplantation but remains intact when grafts were transplanted 1 month prior to allow surgery-induced inflammation to abate. Our findings identify T-reg counter-regulation as a naturally occurring process that accompanies transplantation and an important barrier to T-reg-mediated tolerance. Our finding further highlights the central role of regulatory cell deactivation in the initiation of the immune response.
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