期刊
BIOMATERIALS
卷 28, 期 34, 页码 5144-5147出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2007.07.035
关键词
coagulation; endothelium; non-thrombogenic surfaces; platelets; blood compatibility
资金
- NHLBI NIH HHS [5R01HL064387, R01 HL067923, R01HL67923, R01 HL067923-04, R01 HL064387, R24 HL064387-04] Funding Source: Medline
The biomaterials community has been unable to accurately assign the term blood compatible to a biomaterial in spite of 50 years of intensive research on the subject. There is no clear consensus as to which materials are blood compatible. There are no standardized methods to assess blood compatibility. Since we use millions of devices in contact with blood each year, it is imperative we give serious thought to this intellectual catastrophe. In this perspective, I consider five hypotheses as to why progress has been slow in evolving a clear understanding of blood compatibility: Hypothesis 1-It is impossible to make a blood compatible material. Hypothesis 2-We do not understand the biology behind blood compatibility. Hypothesis 3-We do not understand how to test for or evaluate blood compatibility. Hypothesis 4-Certain materials of natural origin seem to show better blood compatibility but we do not know how to exploit this concept. Hypothesis 5-We now have better blood compatible materials but the regulatory and economic climate prevent adoption in clinical practice. (C) 2007 Elsevier Ltd. All rights reserved.
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