期刊
PIGMENT CELL RESEARCH
卷 20, 期 6, 页码 498-506出版社
BLACKWELL PUBLISHING
DOI: 10.1111/j.1600-0749.2007.00414.x
关键词
ATF2; transcription; DNA damage; stress response; hypoxia; skin cancer; melanoma
资金
- NCI NIH HHS [R01 CA059908-09, R01 CA099961, R01 CA051995, CA051995, R01 CA099961-03, R01 CA051995-13, CA099961, R01 CA059908] Funding Source: Medline
Signal transduction pathways play a key role in the regulation of key cellular processes, including survival and death. Growing evidence points to changes in signaling pathway that occur during skin tumor development and progression. Such changes impact the activity of downstream substrates, including transcription factors. The activating transcription factor 2 (ATF2) has been implicated in malignant and non-malignant skin tumor developments. ATF2 mediates both transcription and DNA damage control, through its phosphorylation by JNK/p38 or ATM/ATR respectively. Here, we summarize our present understanding of ATF2 regulation, function and contribution to malignant and non-malignant skin tumor development.
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