期刊
AMERICAN JOURNAL OF THERAPEUTICS
卷 15, 期 3, 页码 256-264出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MJT.0b013e3181671c5a
关键词
chronic pain; burden; treatment; opioids; tramadol
The burden of chronic/persistent pain is substantial for the patient and society as a whole. Although a variety of pharmacologic treatments are available, chronic/persistent pain remains inadequately treated. Many pharmacologic treatment options provide analgesic efficacy for 4 to 6 hours, requiring multiple doses for continuous pain relief. The inconvenience of multiple doses may prevent many patients from achieving adequate pain relief. Other limitations to the current pharmacologic treatment options include gastrointestinal effects, cardiovascular effects, and organ toxicity, as well as fear of abuse or addiction. The purpose of this review is to highlight the burden of chronic/persistent pain in today's society and discuss the limitations of short-acting pharmacologic therapies used in the treatment of chronic/persistent pain.
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