期刊
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
卷 128, 期 6, 页码 994-1001出版社
AMER SOC CLINICAL PATHOLOGY
DOI: 10.1309/YXR3PKK4TV3DJC56
关键词
laser microdissection; cribriform-morular variant of papillary thyroid carcinoma; clonal analysis; thyroid carcinoma; APC; adenomatous polyposis coli gene
类别
Cribriform-morular variant (C-MV) of papillary thyroid carcinoma (PTC) is a rare and unusual neoplasm composed of multiple histologic components, including cribriform, papillary, solid, tall columnar, and morular patterns. Analyses of gross C-MV of PTC lesions has linked adenomatous polyposis coli (APC) mutations to its pathogenesis; however, the extent of involvement of mutations in the development Of individual components is unclear We report on bidirectional sequencing of the mutation cluster region (codons 1032-1565) of the APC gene in individually laser-microdissected components of a previously unreported C-MV of PTC. A silent Thr1493Thr gene variant was found in all tumoral components, whereas a 5-base-pair frameshift deletion at codon 1309 was identified only in the morules. Neither variant was observed in matched normal thyroid tissue. These results show the histologic components of C-MV of PTC to have some common mutational background, although additional somatic mutations may be involved in the development of morular structures.
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