期刊
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
卷 197, 期 6, 页码 -出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.ajog.2007.04.008
关键词
ghrelin; human placenta; hypoxic ischemia; insulin-like growth factors; leptin
OBJECTIVE: Hypoxia-inducible transcription factors (HIFs) have been characterized as the most important regulators of O-2-dependent gene transcription. We investigated expression of HIF-dependent growth factors and HIF-independent somatotrophic factors in term placenta in response to hypoxic ischemia. STUDY DESIGN: Our cross-sectional in vivo analysis included term placentas of gestations complicated by the following: ( 1) birth asphyxia (n = 22); ( 2) chronic hypoxic ischemia ( n = 22); and ( 3) controls ( n = 28). Gene expression of leptin, insulin-like growth factor (IGF)-1, IGF-2, ghrelin, and human placental growth hormone (hPGH) were measured by Taq-Man reverse transcriptase-polymerase chain reaction. RESULTS: Acute and chronic hypoxia significantly increased leptin messenger ribonucleic acid ( mRNA) levels, compared with controls (P <.001). Augmented IGF-2 mRNA levels were present in chronic hypoxia ( P <.001) but not in birth asphyxia. IGF-1, ghrelin, and hPGH mRNA levels did not change in relation to hypoxia. CONCLUSION: IGF-2 and leptin are suggested to be involved in adaptive response to hypoxic ischemia in term placenta with differential transcriptional regulation related to the duration of hypoxia.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据