期刊
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
卷 343, 期 2, 页码 155-161出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MAJ.0b013e31821f978d
关键词
Autophagy; Cancer; ATG genes; Tumorigenesis; Chemotherapy
资金
- National Natural Science Foundation of China [30870364]
- Science and Technology Support Program of Gansu Province, China [0708NKCA129]
Autophagy is an intracellular lysosome-dependent catabolic process that is indispensable for maintaining cellular homeostasis through the turnover and elimination of defective or redundant proteins and damaged or aged organelles. Recent studies suggest that autophagy may be closely associated with tumorigenesis and the response of tumor cells to chemotherapeutic drugs. This article reviews recent advances in understanding the molecular mechanisms underlying the regulation of autophagy and the role of autophagy in oncogenesis and anticancer therapy. It is paradoxical that autophagy acts as a mechanism for tumor suppression and contributes to the survival of tumors. In addition, whether autophagy in response to chemotherapies results in cell death or instead protects cancer cells from death is complicated, depending on the nature of the cancer and the drug.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据