期刊
GENOMICS
卷 90, 期 6, 页码 690-702出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ygeno.2007.08.006
关键词
QTG; QTL; recombinant QTL introgression; RQI; genetics; gene identification; alcohol drinking; alcoholism; psychiatric disorders
资金
- NIAAA NIH HHS [AA11031] Funding Source: Medline
Alcoholism is a heritable disease that afflicts about 8% of the adult Population. Its development and symptoms, such as craving, loss of control, physical dependence, and tolerance, have been linked to changes in mesolimbic, mesocortical neurotransmitter systems utilizing biogenic amines, GABA. and glutamate. Identification of genes predisposing to alcoholism, or to alcohol-related behaviors in animal models. has been elusive because of variable interactions of multiple genes with relatively small individual effect size and sensitivity of the predisposing genotype to lifestyle and environmental factors. Here, using near-isogenic advanced annual models with reduced genetic background interactions, we integrate gene mapping and gene mRNA expression data in segregating and congenic mice and identify glutamate receptor metabotropic 7 (Grm7) as a cis-regulated gene for alcohol consumption. Traditionally, the mesoaccumbal dopamine reward hypothesis of addiction and the role of the ionotropic glutamate receptors have been emphasized. Our results lend support to an emerging direction of research on the role of metabotropic glutamate receptors in alcoholism and drug addiction. These data suggest for the first time that Grm 7 is a risk factor for alcohol drinking and a new target in addiction therapy. (c) 2007 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据