期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 35, 期 -, 页码 1385-1388出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST0351385
关键词
genome stability; DNA replication; proliferating-cell nuclear antigen (PCNA); small ubiquitin-related modifier (SUMO); Srs2; yeast
Attachment of the SUMO (small ubiquitin-related modifier) to the replication factor PCNA (proliferating-cell nuclear antigen) in the budding yeast has been shown to recruit a helicase, Srs2, to active replication forks, which in turn prevents unscheduled recombination events. In the present review, I will discuss how the interaction between SUMOylated PCNA and Srs2 serves as an example for a mechanism by which SUMO modulates the properties of its targets and mediates the activation of downstream effector proteins.
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