期刊
INTERNATIONAL JOURNAL OF HYPERTHERMIA
卷 31, 期 4, 页码 421-432出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/02656736.2015.1009501
关键词
MRgHIFU; thermal effects; pre-focal interactions; rib cage
资金
- Swiss National Foundation of Science [CR32I3_125499, CR33I3_143980]
- La fondation pour la lutte contre le cancer et pour des recherches medicobiologiques, Geneva, Switzerland
- Swiss National Science Foundation (SNF) [CR33I3_143980, CR32I3_125499] Funding Source: Swiss National Science Foundation (SNF)
Objective: The aim of this paper is to quantitatively investigate the thermal effects generated by the pre-focal interactions of a HIFU beam with a rib cage, in the context of minimally invasive transcostal therapy of liver malignancies. Materials and methods: HIFU sonications were produced by a phased-array MR-compatible transducer on Turkey muscle placed on a sheep thoracic cage specimen. The thoracic wall was positioned in the pre-focal zone 3.5 to 6.5 cm below the focus. Thermal monitoring was simultaneously performed using fluoroptic sensors inserted into the medullar cavity of the ribs and high resolution MR-thermometry (voxel: 1 x 1 x 5 mm(3), four multi-planar slices). Results: MR-thermometry data indicated nearly isotropic distribution of the thermal energy at the ribs' surface. The temperature elevation at the focus was comparable with the pericostal temperature elevation around unprotected ribs, while being systematically inferior, by more than a factor of four on average, to the intra-medullar values. The spatial profiles of the pericostal and intra-medullar thermal build-up measurements could be smoothly connected using a Gaussian function. The dynamics of the post-sonication thermal relaxation as determined by fluoroptic measurements was demonstrated to be theoretically coherent with the experimental observations. Conclusion: The experimental findings motivate further efforts for the transfer towards clinical routine of effective rib-sparing strategies for hepatic HIFU.
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