期刊
EUROPEAN JOURNAL OF CANCER
卷 43, 期 18, 页码 2651-2657出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ejca.2007.07.025
关键词
midgut carcinoid tumour; urinary 5-HIAA level; survival; prognostic factors; neuroendocrine tumours
类别
Survival of patients with disseminated midgut carcinoid tumours varies. We investigated which factors predict survival at referral and during follow-up, with emphasis an urinary 5-hydroxyindolacetic acid (5-HIAA) levels. Between 1992 and 2003, 76 patients were studied; urine was prospectively collected over a 24 h period every 3 months in order to measure 5-HIAA levels. Uni- and multivariate analyses were performed. Median follow-up was 55 months with a median survival of 54 months. Prognostic factors for poor survival were high age, high gamma-glutamyltransferase levels and greatly increased S-HIAA levels (> 20 mmol/mol creatinine) The Hazard Ratio (HR) of a greatly increased 5-HIAA level was 3.33 (95% confidence interval (CI) 1.66-6.66, p = 0.001). In a multivariate survival analysis with the 5-HIAA level as time dependent covariable, the HR for the 5-HIAA level was 1.007 (95% CI 1.004-1.010, p = 0.000). In conclusion, patients with persistent moderately increased urinary 5-HIAA levels (<= 20 mmol/mol creatinine) have favourable outcome. (c) 2007 Elsevier Ltd. All rights reserved.
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