期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 51, 期 12, 页码 4484-4485出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00708-07
关键词
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Intrinsic novobiocin resistance in Staphylococcus saprophyticus was associated with expression of a novobiocin-resistant form of the drug target protein (GyrB). Site-directed mutagenesis established that resistance depends upon the presence of two specific amino acid residues in GyrB: a glycine at position 85 and a lysine at position 140.
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