期刊
BRAIN
卷 130, 期 -, 页码 3149-3154出版社
OXFORD UNIV PRESS
DOI: 10.1093/brain/awm186
关键词
corpus callosum; temporal lobe epilepsy; MRI
资金
- NCRR NIH HHS [P41 RR013642-11, P41 RR013642, R21 RR019771, R21 RR019771-02, U54 RR021813, RR019771] Funding Source: Medline
- NIA NIH HHS [AG016570, P50 AG016570] Funding Source: Medline
- NIBIB NIH HHS [EB01651] Funding Source: Medline
- NICHD NIH HHS [HD050735, R01 HD050735-02, R01 HD050735] Funding Source: Medline
- NINDS NIH HHS [NS049194] Funding Source: Medline
We analysed the influence of mesial temporal lobe epilepsy on the thickness of the corpus callosum (CC) in a large sample of well-characterized patients (n = 96) and healthy controls (n = 28). In particular, we investigated whether callosal structures are differentially affected depending on the affected hemisphere and age of epilepsy onset. Overall, we observed that epilepsy is associated with a decreased thickness in posterior callosal regions. Patients with an early onset, especially patients with left onset, additionally exhibited a smaller callosal thickness in more anterior and midbody regions. These findings may reflect non-specific as well as specific effects of temporal lobe epilepsy on CC development and interhemispheric connectivity.
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