期刊
INTERNATIONAL JOURNAL OF HYPERTHERMIA
卷 31, 期 2, 页码 90-106出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/02656736.2014.997809
关键词
Drug delivery; microbubble; molecular imaging; targeted ultrasound contrast agents; therapy
资金
- Center for Translational Molecular Medicine
- Dutch Heart Foundation (PARISk)
- NanoNextNL, a micro and nanotechnology consortium of the Government of the Netherlands
- Netherlands Organisation for Scientific Research (NWO)
Ultrasound contrast agents (UCAs) are used routinely in the clinic to enhance contrast in ultrasonography. More recently, UCAs have been functionalised by conjugating ligands to their surface to target specific biomarkers of a disease or a disease process. These targeted UCAs (tUCAs) are used for a wide range of pre-clinical applications including diagnosis, monitoring of drug treatment, and therapy. In this review, recent achievements with tUCAs in the field of molecular imaging, evaluation of therapy, drug delivery, and therapeutic applications are discussed. We present the different coating materials and aspects that have to be considered when manufacturing tUCAs. Next to tUCA design and the choice of ligands for specific biomarkers, additional techniques are discussed that are applied to improve binding of the tUCAs to their target and to quantify the strength of this bond. As imaging techniques rely on the specific behaviour of tUCAs in an ultrasound field, it is crucial to understand the characteristics of both free and adhered tUCAs. To image and quantify the adhered tUCAs, the state-of-the-art techniques used for ultrasound molecular imaging and quantification are presented. This review concludes with the potential of tUCAs for drug delivery and therapeutic applications.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据