期刊
PLOS COMPUTATIONAL BIOLOGY
卷 3, 期 12, 页码 2546-2558出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pcbi.0030253
关键词
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资金
- NIGMS NIH HHS [R37 GM023441, GM023441] Funding Source: Medline
Swarming, a collective motion of many thousands of cells, produces colonies that rapidly spread over surfaces. In this paper, we introduce a cell-based model to study how interactions between neighboring cells facilitate swarming. We chose to study Myxococcus xanthus, a species of myxobacteria, because it swarms rapidly and has well-defined cell-cell interactions mediated by type IV pili and by slime trails. The aim of this paper is to test whether the cell contact interactions, which are inherent in pili-based S motility and slime-based A motility, are sufficient to explain the observed expansion of wild-type swarms. The simulations yield a constant rate of swarm expansion, which has been observed experimentally. Also, the model is able to quantify the contributions of S motility and A motility to swarming. Some pathogenic bacteria spread over infected tissue by swarming. The model described here may shed some light on their colonization process.
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