期刊
CURRENT OPINION IN CHEMICAL BIOLOGY
卷 11, 期 6, 页码 595-603出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2007.10.002
关键词
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资金
- NIGMS NIH HHS [R01 GM081652-01, R01 GM081652, GM081652] Funding Source: Medline
Among proteins of known three-dimensional structure, only a few possess complex topological features such as knotted or interlinked (catenated) protein backbones. Such unusual proteins offer potentially unique insights into folding pathways and stabilization mechanisms. They also present special challenges for both theorists and computational scientists interested in understanding and predicting protein-folding behavior. Here, we review complex topological features in proteins with a focus on recent progress on the identification and characterization of knotted and interlinked protein systems. Also, an approach is described for designing an expanded set of knotted proteins.
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