期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 17, 期 23, 页码 6607-6609出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2007.09.064
关键词
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A new and efficient method for the synthesis of PEG-6-mercaptopurine is described. The key feature of the proposed approach is the protection of the thiol group against metabolic inactivation. Preliminary in vivo and in vitro evaluations of the macromolecular prodrug have been carried out. (c) 2007 Elsevier Ltd. All rights reserved.
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