4.7 Article

HMCO5, herbal extract, inhibits NF-κB expression in lipopolysaccharide treated macrophages and reduces atherosclerotic lesions in cholesterol fed mice

期刊

JOURNAL OF ETHNOPHARMACOLOGY
卷 114, 期 3, 页码 316-324

出版社

ELSEVIER IRELAND LTD
DOI: 10.1016/j.jep.2007.08.029

关键词

HMCO5; herb; atherosclerosis; inflammatory cytokines; NF-kappa B; animal model

向作者/读者索取更多资源

HMCO5 is a herbal extract which comprises of eight different herbs. We studied whether this extract has anti-atherosclerotic effects. In lipopolysaccharide (LPS) stimulated RAW264.7 cells, HMCO5 inhibited NF-kappa B activation as well as NOS promoter activity, inhibited the secretion of TNF-alpha. and IL-1 beta, and directly inhibited the intracellular accumulation of reactive oxygen species. ApoE knock-out mice fed a high-fat high-cholesterol diet with HMCO05 for 10 weeks showed a significant reduction in atherosclerotic lesions. A notable finding was the preservation of the smooth muscle cell layer in the media of aorta in the HMCO5 co-treated mice. HMCO5 treated mice did not show significant decrease in serum level of cholesterol. These results suggest that HMC05 has anti-atherosclerotic effects which in part may be attributable to the inhibition of production of NF-kappa B dependent pro-inflammatory cytokines. (c) 2007 Published by Elsevier Ireland Ltd.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据