期刊
NEURON
卷 56, 期 5, 页码 793-806出版社
CELL PRESS
DOI: 10.1016/j.neuron.2007.09.033
关键词
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资金
- Howard Hughes Medical Institute Funding Source: Medline
- Intramural NIH HHS [Z01 HD008748, Z01 HD008748-06] Funding Source: Medline
- NICHD NIH HHS [HD008748-03] Funding Source: Medline
The organization of neuronal wiring into layers and columns is a common feature of both vertebrate and invertebrate brains. In the Drosophila visual system, each R7 photoreceptor axon projects within a single column to a specific layer of the optic lobe. We refer to the restriction of terminals to single columns as tiling. In a genetic screen based on an R7-dependent behavior, we identified the Activin receptor Baboon and the nuclear import adaptor Importin-alpha 3 as being required to prevent R7 axon terminals from overlapping with the terminals of R7s in neighboring columns. This tiling function requires the Baboon ligand, dActivin, the transcription factor, dSmad2, and retrograde transport from the growth cone to the R7 nucleus. We propose that dActivin is an autocrine signal that restricts R7 growth cone motility, and we demonstrate that it acts in parallel with a paracrine signal that mediates repulsion between R7 terminals.
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