期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 72, 期 25, 页码 9643-9647出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo701942e
关键词
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资金
- NIGMS NIH HHS [P50 GM069663-05, P41 GM079593-02, R01 GM070620, R01 GM070620-04, P50 GM069663, P41 GM079593, R01 GM079593] Funding Source: Medline
[GRAPHICS] A large number of functionally substituted 2-alkyn-1-one O-methyl oximes have been cyclized under mild reaction conditions in the presence of ICI to give the corresponding 4-iodoisoxazoles in moderate to excellent yields. The resulting 4-iodoisoxazoles undergo various palladium-catalyzed reactions to yield 3,4,5-trisubstituted isoxazoles, including valdecoxib.
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