期刊
CANCER LETTERS
卷 258, 期 1, 页码 9-21出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2007.09.004
关键词
neural cell adhesion molecule; NCAM; tumour targeting; monoclonal antibodies; immunotherapy
类别
NCAM is a tumour associated antigen expressed on small cell lung cancer, neuroblastoma, rhabdomyosarkoma, brain tumours, multiple myelomas and acute myeloid leukaemia. Constant and strong expression of NCAM is a prerequisite for the development of antibody-based immunotherapies. From the spectrum of existing anti-NCAM compounds, radioimmunoconjugates and immunotoxins represent the clinically most advanced and successful strategies. Here we provide an overview of the evolving field of anti-NCAM immunotherapy for cancer and discuss its indications and limitations. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
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