期刊
CIRCULATION
卷 116, 期 24, 页码 2802-2808出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/CIRCULATIONAHA.107.704064
关键词
atherosclerosis; collateral circulation; myocardial fractional flow reserve; restenosis; stents
Background-Fractional flow reserve predicts cardiac events after coronary stent implantation. The aim of the present study was to assess the 9-month angiographic in-stent restenosis rate in the setting of optimal stenting and a persisting gradient distal to the stent as assessed by a pressure wire pullback recording in the entire length of the artery. Methods and Results-In 98 patients with angina pectoris, 1 de novo coronary lesion was treated with a bare-metal stent. After stent implantation, pressure wire measurements (P-d=mean hyperemic coronary pressure and P-a=mean aortic pressure) were performed in the target vessel: (1) P-d/P-a as distal to the artery as possible (fractional flow reserve per definition); (2) P-d/P-a just distal to the stent; (3) P-d/P-a just proximal to the stent; and (4) P-d/P-a at the ostium. Residual abnormal P-d/P-a was defined as a pressure drop between P-d/P-a measured at points 1 and 2. Fractional flow reserve distal to the artery after stenting was significantly lower (0.88 +/- 0.21 versus 0.97 +/- 0.05; P < 0.001), and angiographic in-stent binary restenosis rate was significantly higher (44.0% versus 8.1%; P < 0.001) in vessels with a residual abnormal P-d/P-a. Residual abnormal P-d/P-a (odds ratio, 4.39; 95% confidence interval, 1.10 to 18.16; P=0.034), reference vessel size (odds ratio, 0.17; 95% confidence interval, 0.04 to 0.69; P=0.013), and stent length ( odds ratio, 1.11; 95% confidence interval, 1.03 to 1.21; P=0.009) were predictors of angiographic in-stent restenosis after 9 months. Conclusions-A residual abnormal P-d/P-a distal to a bare-metal stent was an independent predictor of in-stent restenosis after implantation of a coronary bare-metal stent.
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