期刊
BEHAVIOURAL BRAIN RESEARCH
卷 185, 期 1, 页码 65-67出版社
ELSEVIER
DOI: 10.1016/j.bbr.2007.07.011
关键词
DOI; serotonin; hypomobility; subthalamic nucleus; deep brain stimulation
Intervening with serotonergic neurotransmission can have profound effects on mobility. For instance, the peripheral administration of the 5HT(2A/c) agonist, 2,5-dimethoxy-4-iodoamphetamine (DOI), changes the locomotor activity substantially. Locomotor activity is classically linked to the basal ganglia, in which the subthalamic nucleus (STN) plays a pivotal role. In this study, we tested the hypothesis that deep brain stimulation (DBS) of the STN modulates DOI-induced hypomobility. Rats were implanted with stimulating electrodes at the level of the STN and were tested in an open field (OF) task in various conditions (stimulation on/off, in combination with DOI treatment). We found that DOI administration (i.p.) reduced the behavioural activity of the animals and that STN HFS reversed these effects. This study provides the first evidence that the therapeutic effect of STN HFS may also be mediated by a 5-HT-dependent mechanism. (C) 2007 Elsevier B.V. All rights reserved.
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