期刊
FEBS LETTERS
卷 581, 期 29, 页码 5703-5708出版社
WILEY
DOI: 10.1016/j.febslet.2007.11.030
关键词
pannexin; innexin; calcium wave; ATP; glia; evolution
资金
- NIGMS NIH HHS [R01 GM048610-13A2, R01 GM048610, GM48610, R01 GM048610-14] Funding Source: Medline
- NINDS NIH HHS [T32 NS007044, R01 NS034927, R01 NS037025, NS34927, NS37025] Funding Source: Medline
Injury to the central nervous system triggers glial calcium waves in both vertebrates and invertebrates. In vertebrates the pannexin1 ATP-release channel appears to provide for calcium wave initiation and propagation. The innexins, which form invertebrate gap junctions and have sequence similarity with the pannexins, are candidates to form non-junctional membrane channels. Two leech innexins previously demonstrated in glia were expressed in frog oocytes. In addition to making gap junctions, innexins also formed non-junctional membrane channels with properties similar to those of pannexons. In addition, carbenoxolone reversibly blocked the loss of carboxyfluorescein dye into the bath from the giant glial cells in the connectives of the leech nerve cord, which are known to express the innexins we assayed. (C) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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