期刊
JOURNAL OF NEUROSCIENCE
卷 27, 期 50, 页码 13756-13761出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.4053-07.2007
关键词
hippocampus; two-photon imaging; EPSP; dentate gyrus; dentate hilus; mossy cell; epilepsy
资金
- NIA NIH HHS [AG00271] Funding Source: Medline
- NINDS NIH HHS [R01-NS33590] Funding Source: Medline
Synaptic reorganization of the dentate gyrus inner molecular layer (IML) is a pathophysiological process that may facilitate seizures in patients with temporal-lobe epilepsy. Two subtypes of IML neurons were originally described by Ramon y Cajal ( 1995), but have not been thoroughly studied. We used two-photon imaging, infrared-differential interference contrast microscopy and patch clamp recordings from rat hippocampal slices to define the intrinsic physiology and synaptic targets of spiny, granule-like neurons in the IML, termed semilunar granule cells (SGCs). These neurons resembled dentate granule cells but had axon collaterals in the molecular layer, significantly larger dendritic arborization in the molecular layer, and a more triangular cell body than granule cells. Unlike granule cells, SGCs fired throughout long-duration depolarizing steps and had ramp-like depolarizations during interspike periods. Paired recordings demonstrated that SGCs are glutamatergic and monosynaptically excite both hilar interneurons and mossy cells. Semilunar granule cells appear to represent a distinct excitatory neuron population in the dentate gyrus that may be an important target for mossy fiber sprouting in patients and rodent models of temporal lobe epilepsy.
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