期刊
VACCINE
卷 25, 期 51, 页码 8518-8528出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2007.10.022
关键词
hMPV; vaccination; formaldehyde; immunopathology; paramyxovirus
Human metapneumovirus (hMPV), a member of the family Paramyxovifidae, is an important cause of acute respiratory tract disease. In the 1960s, vaccination with formalin-inactivated paramyxovirus preparations - respiratory syncytial virus (RSV) and measles virus (MV) resulted in predisposition for enhanced disease upon natural infection. We have produced a formalin-inactivated hMPV preparation (FI-hMPV), which was used to immunize young cynomolgus macaques. Six days after challenge FI-hMPV-primed monkeys had developed eosinophilic bronchitis and bronchiolitis, indicative of a hypersensitivity response. This study indicates that formalin-inactivated hMPV vaccines have the same propensity to predispose for immune-mediated disease as inactivated RSV and MV vaccines. (c) 2007 Elsevier Ltd. All rights reserved.
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