Calcium ions (Ca2+) impact nearly every aspect of cellular life. This review examines the principles of Ca2+ signaling, from changes in protein conformations driven by Ca2+ to the mechanisms that control Ca2+ levels in the cytoplasm and organelles. Also discussed is the highly localized nature of Ca2+- mediated signal transduction and its specific roles in excitability, exocytosis, motility, apoptosis, and transcription.
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