期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 17, 期 24, 页码 6891-6894出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2007.10.009
关键词
TNF-alpha; IL-6; inhibitors; andrographolide; derivatives; synthesis
The synthesis of a series of andrographolide derivatives was described and their inhibitory effects on TNF-alpha and IL-6 secretion in mouse macrophages were also evaluated. Most of the tested compounds showed inhibitory effects, and the compounds with the structure of 12-hydroxy-14-dehydroandrographolide showed better inhibitory activity than the compounds with the structure of isoandrographolide. (c) 2007 Elsevier Ltd. All rights reserved.
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