Is the corrected-creatinine Model for End-stage Liver Disease a feasible strategy to adjust gender difference in organ allocation for liver transplantation?

Background. The Model for End-stage Liver Disease (MELD) scoring system is used for organ allocation in liver transplantation. Female cirrhotic patients have lower glomerular filtration rates (GFR) than males for the same creatinine (Cr) level. Correcting the Cr in females for the same GFR as in males shows that females have lower MELD scores and therefore a lower priority for liver transplantation; however, there has been no outcome data that justifies this modification. Methods. We investigated 472 cirrhotic patients, comparing the mortality rate between males and females in relation to MELD and corrected-Cr MELD. Results. Compared to females, male patients had a higher MELD (14.5 +/- 5.5 vs. 13.8 +/- 5.7) and significantly higher GFR (61.7 +/- 21.4 vs. 54.7 +/- 25.6 mlLmin/ 1.73 m(2), p= 0.0002) because their Cr value was higher (1.4 +/- 0.4 vs. 1.3 +/- 0.5 mg/dL, P= 0.0002). The corrected-Cr MELD score in females was higher (15.7 +/- 6.3) compared to the MELD in their original counterpart (P<0.0001) and the males (P=0.060). Female and male patients had a similar 3-month mortality rate (6.7% vs. 6.3%) and MELD (21.9 +/- 8.6 vs. 21.7 +/- 8.9) among deceased patients. At 6 months, female patients tended to have a lower mortality (12.5% vs. 14.7%) and a lower MELD (18.9 +/- 7.7 vs. 19.4 +/- 8.5) in deceased patients. However, at 9 and 12 months, females had a consistently higher mortality (25% vs. 21.2% and 37.5% vs. 31.3%, respectively) but lower MELD scores than males by 0.3-1 point. Conclusions. Using corrected-Cr MELD, which would prioritize female patients for liver transplantation, may only be justified in predicting intermediate-term (9- and 12-month), but not short-term (3- and 6-month) mortality.