期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 15, 期 24, 页码 7647-7660出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2007.08.065
关键词
hetero Diels-Alder reaction; tetrahydroimidazo[2,1-a] isoquinolines; antisecretory activity; gastric acid pump; H+/K+-ATPase
A series of novel tetrahydroimidazo[2,1-a] isoquinolines was prepared based on a hetero Diels-Alder reaction between an enamine and 1,2,4-triazine as key step. A structure-activity relationship was established focussing on the in. uence of the substitution pattern in position 3 and 6 of the heterocycle on antisecretory activity, lipophilicity, and pK(a) value. Potent inhibitors of the gastric acid pump were identified. (c) 2007 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据