期刊
JOURNAL OF INFECTIOUS DISEASES
卷 196, 期 12, 页码 1844-1851出版社
UNIV CHICAGO PRESS
DOI: 10.1086/522968
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资金
- NIAID NIH HHS [R01 AI022662, R01 AI022662-22, R01 AI 50668, R01 AI050668-08, R01 AI 47189, R01 AI050668, R01 AI 22662, R01 AI047189] Funding Source: Medline
The objective of the present study was to explore the ability of eosinophils to present Strongyloides stercoralis antigen in naive and immunized mice. Antigen-pulsed eosinophils were injected intraperitoneally into naive or immunized mice, and then mice were examined for antigen-specific immune responses. A single inoculation of antigen-pulsed eosinophils was sufficient to prime naive mice and to boost immunized mice for antigen-specific T helper cell type 2 (Th2) immune responses with increased interleukin (IL)-4 and IL-5 production. Mice inoculated 3 times with live eosinophils pulsed with antigen showed significant increases in parasite antigen-specific immunoglobulin (Ig) Mand IgG levels in their serum. Antigen-pulsed eosinophils deficient in major histocompatibility complex class II molecules or antigen-pulsed dead eosinophils failed to induce immune responses, thereby demonstrating the requirement for direct interaction between eosinophils and T cells. These experiments demonstrate that eosinophils function as antigen-presenting cells for the induction of the primary and the expansion of the secondary Th2 immune responses to S. stercoralis in mice.
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