4.7 Article

Berberine, a natural isoquinoline alkaloid, induces NAG-1 and ATF3 expression in human colorectal cancer cells

期刊

CANCER LETTERS
卷 258, 期 2, 页码 230-240

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ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2007.09.007

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berberine; NAG-1; ATF3; apoptosis; p53

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资金

  1. NCI NIH HHS [R21 CA109423, R21CA 109423, R21 CA109423-01A1] Funding Source: Medline

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Berberine is known to possess a wide variety of pharmacological activities, including pro-apoptotic activity. However, its molecular targets are not elucidated at present. NAG-1 and ATF3 are induced by several dietary compounds associated with pro-apoptotic activity. Berberine induces cell growth arrest, apoptosis, NAGA, and ATF3 in human colorectal cancer cells. ATF3 induction by berberine is mediated in a p53-dependent manner, whereas NAG-I induction by berberine is mediated by multiple signaling pathways. Our results suggest that berberine facilitates apoptosis and that NAG-1 and ATF3 expression plays an important role in berberine-induced apoptosis. (c) 2007 Elsevier Ireland Ltd. All rights reserved.

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