期刊
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
卷 32, 期 10, 页码 1523-1531出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/PAS.0b013e31816b6478
关键词
DLBCL; germinal center; prognosis; SIRT1; p53
资金
- Korean Government (MOGHRD)
- National R&D Program for Cancer Control, Ministry of Health and Welfare, Republic of Korea [(0620220-1)]
Sirtuin1 (SIRT1) is a nicotinamide adenine dinucleotide-dependent deacetylase. Recently, it is suggested that SIRT1 may be involved in the development of malignant tumors including mouse lymphoma. Therefore, we investigated the prevalence and the prognostic impact of SIRTI expression in diffuse large B-cell lymphoma (DLBCL). Immunohistochemical expression of SIRT1, p53, bcl2, CD10, bcl6, and multiple myeloma-1 (MUM1) were evaluated by using a 2mm core from 104 DLBCL patients for tissue microarray. Positive expression of SIRTI was seen in 74% (77/104) of patients. In total DLBCL patients, SIRTI and p53 expression were significantly associated with shorter overall survival (OS) by univariate analysis (P = 0.001 and P = 0.011, respectively). SIRTI was also an independent prognostic factor by multivariate analysis (P = 0.01). According to the expression patterns of CD 10, bcl6, and MUM 1, germinal center B cell (GCB) types were represented in 38 cases (37%,) and non-GCB types were represented in 66 cases (63%). In the GCB type, only p53 expression was associated with a significantly shorter OS (P = 0.032). In the non-GCB type, expression of SIRTI correlated with shorter OS by univariate analyses (P = 0.005) and multivariate analyses (P = 0.049). In conclusion, we showed that SIRTI expression is a clinically significant prognostic indicator for DLBCL patients.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据