期刊
FEBS LETTERS
卷 582, 期 1, 页码 2-9出版社
WILEY
DOI: 10.1016/j.febslet.2007.11.016
关键词
orphan nuclear receptor; metabolic syndrome; obesity; insulin resistance; dyslipidemia
资金
- Howard Hughes Medical Institute Funding Source: Medline
- NHLBI NIH HHS [R01 HL105278] Funding Source: Medline
- NIDDK NIH HHS [U19 DK062434, R37 DK057978] Funding Source: Medline
Nuclear receptors (NR) are a superfamily of ligand-activated transcription factors that regulate development, reproduction, and metabolism of lipids, drugs and energy. The importance of this family of proteins in metabolic disease is exemplified by NR ligands used in the clinic or under exploratory development for the treatment of diabetes mellitus, dyslipidemia, hypercholesterolemia, or other metabolic abnormalities. Genetic studies in humans and rodents support the notion that NRs control a wide variety of metabolic processes by regulating the expression of genes encoding key enzymes, transporters and other proteins involved in metabolic homeostasis. Current knowledge of complex NR metabolic networks is summarized here. (C) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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