期刊
CARDIOVASCULAR RESEARCH
卷 77, 期 2, 页码 293-301出版社
OXFORD UNIV PRESS
DOI: 10.1093/cvr/cvm004
关键词
ventricular arrhythmias; SR (function); sudden death; e-c coupling; calcium (cellular)
资金
- Telethon [GP0227Y01] Funding Source: Medline
Development of cardiac arrhythmias in several degenerative cardiac disorders such as heart failure is precipitated by abnormalities in intracellular calcium regulation. Recently, the identification of mutations in proteins responsible for the control of intracellular calcium has been associated with an inherited arrhythmogenic syndrome called catecholaminergic polymorphic ventricular tachycardia (CPVT). Here, we review the current knowledge about the molecular pathophysiology of CPVT and we discuss some potentially innovative strategies for controlling calcium-handling abnormalities in CPVT that may provide novel therapeutic options for affected patients.
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