期刊
CLINICAL PHARMACOLOGY & THERAPEUTICS
卷 83, 期 2, 页码 251-257出版社
WILEY
DOI: 10.1038/sj.clpt.6100267
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资金
- Korea Health Promotion Institute [A030001] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [kosefR01-2001-000-00208-0] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
This study was carried out to determine whether polymorphisms of organic anion-transporting polypeptide 1B1 (OATP1B1) have an effect on rosuvastatin pharmacokinetics in Koreans. Among 200 subjects genotyped for OATP1B1 c.388A>G, and c.521T>C, 30 subjects were selected for the rosuvastatin pharmacokinetic study. The area under the concentration-time curve for 0 to infinity (AUC(0-infinity)) of rosuvastatin for group 1 (*1a/*1a, *1a/*1b, *1b/*1b), group 2 (*1a/*15, *1b/*15), and group 3 (*15/*15) were 111 +/- 49.3, 126 +/- 45.2, and 191 +/- 31.0 ng h/ml, respectively, with significant differences among the three groups (P=0.0429) and between (*15/*15) and the other groups (P=0.0181). The maximum plasma concentration (C-max) also showed a significant difference between (*15/*15) and the other groups (P=0.0181). There were no significant differences in rosuvastatin-lactone pharmacokinetics among the three groups. The pharmacokinetic exposure of rosuvastatin was higher in the OATP1B1*15/*15 subjects than the others, suggesting a potential association between the OATP1B1 genetic polymorphisms and altered rosuvastatin pharmacokinetics in Korean populations.
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