期刊
AMERICAN JOURNAL OF SURGERY
卷 197, 期 3, 页码 348-352出版社
EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
DOI: 10.1016/j.amjsurg.2008.11.010
关键词
Lymph node ratio; Pancreaticoduodenectomy; Pancreatic adenocarcinoma; Ampullary adenocarcinoma; Duodenal adenocarcinoma; Cholangiocarcinoma
类别
BACKGROUND: Lymph node ratio (LNR) has been associated with long-term survival in patients with pancreatic adenocarcinoma; however, this has not been demonstrated in other periampullary malignancies. The put-pose of this study was to determine if LNR is associated with survival in other periampullary malignancies. METHODS: A retrospective review of a prospective database of 522 pancreaticoduodenectomies (PDs) performed between 1988 and 2007 was undertaken. Clinicopathologic data were collected, and LNR was calculated. Patients with positive lymph node (LN) status were placed into the following groups: (1) LNR = 0; (2) LNR <= 0.2; (3) LNR <= 0.4; and (4) LNR >0.4. RESULTS: Of the 364 malignancies identified, there were 219 (60%) pancreatic adenocarcinomas, 36 (10%) duodenal adenocarcinomas, 75 (21%) ampullary adenocarcinomas, and 35 (10%) cholangiocarcinomas. Positive LN status affected patient survival in all malignancies studied. Increasing LNR is associated with decreased survival in PA (P = .03) and AA (P = .04). CONCLUSIONS: Positive LN status in all patients with periampullary malignancies is associated with worse survival rates than in those with no evidence of disease. LNR is inversely associated with survival rates in pancreatic and ampullary adenocarcinoma patients. 0 2009 Published by Elsevier Inc.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据